Signaling Crosstalk: Integrating Nutrient Availability and Sex

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic glucose metabolism. Postnatal ablation of insulin receptors (IRs) in glial fibrillary acidic protein (GFAP)-expressing cells affects hypothalamic astrocyte morphology, mitochondrial function, and circuit connectivity. Accordingly, astrocytic IR ablation reduces glucose-induced activation of hypoth...

Environmental sex determination in ferns: effects of nutrient availability and individual density in Woodwardia radicans

1. In environmental sex determination (ESD) gender is decided after conception, depending on the environment, rather than being genetically fixed. ESD in plants has been mainly studied in angiosperms, where the dominant form of ESD is sexual lability. Surprisingly, ESD has rarely been studied in homosporous ferns, the only plants in which ESD is the rule, rather than the exception. 2. Here, we ...

Nutrient availability links mitochondria, apoptosis, and obesity

Mitochondria are the dominant source of the cellular energy requirements through oxidative phosphorylation, but they are also central players in apoptosis. Nutrient availability may have been the main evolutionary driving force behind these opposite mitochondrial functions: production of energy to sustain life and release of apoptotic proteins to trigger cell death. Here, we explore the link be...

Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism.

As obesity, diabetes, and associated comorbidities are on a constant rise, large efforts have been put into better understanding the cellular and molecular mechanisms by which nutrients and metabolic signals influence central and peripheral energy regulation. For decades, peripheral organs as a source and a target of such cues have been the focus of study. Their ability to integrate metabolic s...

Content Availability and Signaling Overhead